Figure 1.
Fig. 1. Orientation of the inhibitor in the active site and
arrangement of the central vicinal hydroxyls (stereo view). The
figure shows the structure of the asymmetric compound 3 as it is
arranged in the HIV-1 protease active site. The electron density
map indicates a unique orientation of the inhibitor and the
whole protease–inhibitor complex in the crystal lattice. The
density also indicates an 90% unique
orientation of the central vicinal hydroxy groups in the complex
with this compound. The Fo–Fc electron density map was
calculated at 2.0 Å resolution with the inhibitor compound
omitted, and contoured at 2.5 .
The above figure is reprinted
by permission from the Federation of European Biochemical Societies:
Eur J Biochem
(2003,
270,
1746-1758)
copyright 2003.
90% unique
orientation of the central vicinal hydroxy groups in the complex
with this compound. The Fo–Fc electron density map was
calculated at 2.0 Å resolution with the inhibitor compound
omitted, and contoured at 2.5 
.