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Figure 1.
Figure 1. The Structure of the BMP7/ActRII-ECD Complex(A
and B) Ribbon diagrams of the BMP7/ActRII-ECD complex (A) with
the 2-fold symmetry axis vertical and the membrane facing side
at the bottom and (B) the view from above (BMP7, gold and rust;
ActRII-ECD, green; cystine sulfurs, yellow space-filling).(C)
Stereo view of the interface between BMP7 and ActRII in an
orientation close to (A). The residues within 4 Å of the
binding partner as well as Glu29 are displayed as balls and
sticks. Glu29 and those residues whose mutations are known to
affect binding (pink, Figure 2) are labeled.In (A)–(C)
significant conformational changes are highlighted (dark blue),
and in (C) they are overlaid with the unbound conformations
(light blue). This figure was made using MOLSCRIPT (Kraulis,
1991).
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