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Figure 1.
Fig. 1. Chemical structures of peptidyl transferase
substrate analogues. (A) CCA-pcb is active as a P site substrate
and binds to only the P site in the presence of the antibiotic,
sparsomycin. (B) An aminoacylated RNA minihelix binds to the A
site. (C) CCdA-phosphate-puromycin is an intermediate analogue
containing A and P site-binding components. (D)
CC-puromycin-phenylalanine-caproic acid-biotin and deacylated
CCA are products of the peptidyl transferase reaction.
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