Figure 1 - full size

 

Figure 1.
Fig. 1. Mechanism of the acetyltransferase reaction catalyzed by AANAT (A) and alkyl transfer between CoASH and N-bromoacetyltryptamine (compound 1), resulting in the bisubstrate analog inhibitor (compound 2) (B).

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2002, 277, 18118-18126) copyright 2002.