|
Figure 1.
Figure 1. Non-mevalonate pathway of isopentenyl and
dimethylallyldiphosphate biosynthesis. (a) Pyruvate and
glyceraldehyde 3-phosphate are condensed to (b) 1-deoxy- Image
-xylulose 5-phosphate, which is converted into (c) 2C-methyl-
Image -erythritol 4-phosphate. Condensation with CTP yields (d)
4-diphosphocytidyl-2C-methyl- Image -erythritol, which is
converted into (d) 4-diphosphocytidyl-2C-methyl- Image
-erythritol 2-phosphate. The last step identified so far is the
cyclisation of the latter to (f) 2C-methyl- Image -erythritol
2,4-cyclodiphosphate by IspF.
|
