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Figure 1.
Figure 1: Interaction of chloramphenicol with the peptidyl
transferase cavity. a, Chemical structure diagram of
chloramphenicol showing the interactions (arrows) of its
reactive groups with the nucleotides of the peptidyl transferase
cavity. Arrows between two chemical moieties indicate that the
two groups are less than 4.4 Å apart. b, Secondary structure of
the peptidyl transferase ring of D. radiodurans showing the
nucleotides involved in the interaction with chloramphenicol
(coloured nucleotides). The colours in the secondary structure
diagram match those of the chemical diagram. c, Stereo view
showing the nucleotides interacting with chloramphenicol at the
peptidyl transferase cavity of D. radiodurans. The difference
electron density map (2F[o] - F[c]) is contoured at 1.2  .
The antibiotic is shown in green. Nucleotide numbering is
according to the E. coli sequence. Putative Mg ions (Mg-C1,
Mg-C2) are indicated.
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