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Figure 1.
Figure 1. Overall Structure of the DIAP1-BIR2 Domain by
Itself (A) and in Complex with the Grim (B) or Hid (C)
PeptideThe DIAP1-BIR2 domain is shown in cyan and the bound Grim
and Hid peptides are highlighted in orange and pink,
respectively. The zinc atom in the BIR domain is colored red,
while its coordinating residues are shown in yellow. Some of the
secondary structural elements are labeled. In (D), the
structures of DIAP1-BIR2 by itself and in complex with the
Hid/Grim peptides are superimposed with that of XIAP-BIR3 in
complex with the Smac tetrapeptide (Protein Data Bank code
1G73). The DIAP1-BIR2 and XIAP-BIR3 are shown in cyan and
purple, respectively. The bound Grim and Hid peptides are
highlighted in orange and pink, respectively, while the Smac
tetrapeptide is represented in green. Helix α6, highlighted in
red, is only present in the peptide-bound BIR2
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