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Figure 1.
Fig. 1. Receptor binding of vMIP-II and SDF-1 based
N-terminal peptides and chemotaxis inhibition by
vMIP-II(1–10). A: Competition for specific binding of
^125I-SDF-1 (4 nM) to CEM cells by SDF-1 (open circle),
SDF(1–9) monomer (open triangle), SDF(1–9)dimer (closed
triangle), vMIP-II(1–10) (open square), vMIP-II(1–11)dimer
(closed square) and N-MDC (square with cross). The data for the
N-terminal peptides of IP-10, eotaxin and eotaxin-2 are not
shown. The results are representative of duplicate experiments.
B: CEM cell migration induced by concentrations of
SDF(1–9)dimer (closed circle) and the antagonist
vMIP-II(1–10) (open triangle). Data are the means of ±S.D. of
duplicate determinations from two separate experiments.
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