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Figure 1.
Fig. 1. Scheme of the reaction catalyzed by antibody 4B2.
4B2 catalyzes allylic rearrangement of  -cyclopent-1-en-1-yl-p-acetamidophenone
2 to -cyclopentylidien-p-acetamidophenone
4 via the enediol intermediate 3,
2-[4-(1-carboxy)propylamidobenzylamino]-3,4,5,6-tetrahydropyridinium.
1a is the hapten used to generate 4B2. The structure that was
determined is that of the complex of 4B2 with
2-(4-aminobenzylamino)-3,4,5,6-tetrahydropyridinium 1b. Antibody
5C8 was generated against hapten 5a, and its x-ray structure was
determined in the presence of inhibitor 5b (12).
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