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Figure 1.
Fig. 1. Reaction catalyzed by thioredoxin reductase. Reducing
equivalents from NADPH are transferred to the flavin cofactor,
then to the enzyme disulfide (Cys135-Cys138), and finally to the
disulfide (Cys32-Cys35) of the substrate, oxidized thioredoxin
(30). Reduced thioredoxin is a reductant for ribonucleotide
reductase and an activator of T7 DNA polymerase (31, 32).
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