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Figure 1.
Figure 1. The RARα–RXRαF318A LBD Heterodimer and Its
Component Monomers(A) The dimeric arrangement of hRARα and
mRXRαF318A LBDs is viewed perpendicular to the dimer axis. The
secondary structural elements are labeled according to the
nomenclature of other nuclear receptors ([38]). Helices (H) are
represented as tubes; coil regions are colored in orange; β
strands (s) in red. The dotted line in mRXRαF318A indicates the
unmodeled region between H1 and H3. The ligands in hRARα
(BMS614) and mRXRαF318A (oleic acid, OA) are represented in
yellow.(B) Superposition of the hRARα/BMS614 complex from the
heterodimer crystal structure and the hRARγ/T-RA monomer
complex ([26]).(C) Superposition of the mRXRαF318A/OA LBD from
the heterodimer crystal structure and the hRXRα/9C-RA LBD
monomer crystal structure (P. Egea et al., submitted).(D)
Superposition of the hRARα/BMS614 and the mRXRαF318A/OA LBD
complexes, both from the heterodimer crystal structure.
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