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Figure 1.
Figure 1. Domain Structure of the Neural Cell Adhesion
Molecule Axonin-1/TAG-1Axonin-1/TAG-1 is composed of six Ig
domains that are arranged in a contiguous string in the
N-terminal moiety. The C-terminal moiety of axonin-1/TAG-1
consists of four FnIII domains. A junctional decapeptide
enriched in glycine and proline is interposed between the sixth
Ig and the first FnIII domain. Axonin-1/TAG-1 is anchored to the
cell membrane by a glycosylphosphatidylinositol group (for a
detailed description: [13 and 38]). By domain deletion studies,
the binding sites for the interactions of axonin-1 with NgCAM
and NrCAM have been localized within the first four Ig domains (
[27 and 12]). The results of binding studies with ligand CAMs
and monoclonal antibodies further suggested that the first four
Ig domains of axonin-1 form a unit that is structurally and
functionally intact only when all for domains are present (
[27]).
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