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Figure 1.
Fig. 1. Schematic representation of the complex between
SpA domain D and Fab 2A2 from a human IgM. (A) Side view showing
SpA domain D (red) bound to the framework region of the Fab
heavy chain (cyan). The V[L] domain, which is not involved in
this interaction, is shown in dark blue. The CDR loops as
defined by Chothia and Lesk (33) are highlighted in magenta. (B)
Ribbon representation of the V[H] region of Fab showing the
positions of the residues that interact with domain D. (C)
Schematic diagram detailing the residues of SpA domain D and Fab
2A2 involved in the interaction. Kabat numbering is used for the
V[H] residues (blue); domain D is numbered (in brown) with the
convention used for SpA domains (34). Contact residues are
identified if 20 Å2 or more of their surface are buried in
the interface and if they make at least one van der Waals
contact. All figures were generated by using MOLMOL (35).
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