Figure 1.
Figure 1. GDP-fucose biosynthesis. NADP bound to GMD is
reduced and then oxidized during the course of the reaction. GFS
catalyzes two distinct reactions: the epimerization of the
GDP-4-keto, 6-deoxymannose at C3 and C5 followed by the
subsequent reduction at C4 to yield GDP-fucose.
The above figure is reprinted
by permission from Cell Press:
Structure
(2000,
8,
123-135)
copyright 2000.
