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Title
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Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain.
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Authors
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J.Sun,
S.Tadokoro,
T.Imanaka,
S.D.Murakami,
M.Nakamura,
K.Kashiwada,
J.Ko,
W.Nishida,
K.Sobue.
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Ref.
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Febs Lett, 1998,
437,
304-308.
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PubMed id
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Abstract
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Using monoclonal antibody against the 45 kDa postsynaptic density protein, we
isolated a novel isoform of Homer/vesl. The NH2-terminal region containing a PDZ
domain of this protein is identical to that of Homer/vesl, and the COOH-terminal
region containing unique leucine zippers shows self-multimerization. We named
this protein PSD-Zip45. In addition to specific binding of PSD-Zip45 mediated by
a PDZ domain to the metabotropic glutamate receptors 1alpha or 5, the
distribution of PSD-Zip45 transcripts is highly consistent with that of
metabotropic glutamate receptor transcripts. The PSD-Zip45 is, therefore, the
first candidate as receptor anchoring proteins containing leucine zipper motifs
in the central nervous system.
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