 |
|
Title
|
|
Crystallographic structural studies of a human Fc-fragment. I. An electron-density map at 4 A resolution and a partial model.
|
|
|
Authors
|
|
J.Deisenhofer,
P.M.Colman,
R.Huber,
H.Haupt,
G.Schwick.
|
|
|
Ref.
|
|
Hoppe Seylers Z Physiol Chem, 1976,
357,
435-445.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
The crystal structure of a human Fc fragment was analysed at 4 A resolution. A
partial interpretation of the electron-density map in terms of domain structure
was possible. The molecule has the shape of a mickey mouse. The spherical domain
was interpreted visually and by domain Patterson function interpretation as the
CH3 dimer. This dimer resembles closely the CH1-CL dimer found in Fab
structures. The ellipsoidal "ears" of the molecule represent the CH2 domains.
They are widely separated from each other, but closely connected to CH3. Their
tertiary structure must be different from CH1, as Patterson domain
interpretations were unsuccessful. A chain tracing in CH2 was not yet possible.
|
|
|
|