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Comparative protein modeling is increasingly gaining interest since it is of
great assistance during the rational design of mutagenesis experiments. The
availability of this method, and the resulting models, has however been
restricted by the availability of expensive computer hardware and software. To
overcome these limitations, we have developed an environment for comparative
protein modeling that consists of SWISS-MODEL, a server for automated
comparative protein modeling and of the SWISS-PdbViewer, a sequence to structure
workbench. The Swiss-PdbViewer not only acts as a client for SWISS-MODEL, but
also provides a large selection of structure analysis and display tools. In
addition, we provide the SWISS-MODEL Repository, a database containing more than
3500 automatically generated protein models. By making such tools freely
available to the scientific community, we hope to increase the use of protein
structures and models in the process of experiment design.
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