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Title
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Structure of the receptor binding fragment HC of tetanus neurotoxin.
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Authors
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T.C.Umland,
L.M.Wingert,
S.Swaminathan,
W.F.Furey,
J.J.Schmidt,
M.Sax.
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Ref.
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Nat Struct Biol, 1997,
4,
788-792.
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PubMed id
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Abstract
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The 2.7 A structure of the tetanus neurotoxin receptor binding fragment Hc
reveals a jelly-roll domain and a beta-trefoil domain. Hc retains the unique
transport properties of the holotoxin and is capable of eliciting a protective
immunological response against the full length holotoxin.
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