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Title
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A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs.
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Authors
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A.Shimamoto,
S.Kitao,
K.Ichikawa,
N.Suzuki,
Y.Yamabe,
O.Imamura,
Y.Tokutake,
M.Satoh,
T.Matsumoto,
J.Kuromitsu,
H.Kataoka,
K.Sugawara,
M.Sugawara,
M.Sugimoto,
M.Goto,
Y.Furuichi.
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Ref.
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Proc Natl Acad Sci U S A, 1996,
93,
10913-10917.
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PubMed id
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Abstract
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A unique gene, RBP-MS, spanning over 230 kb in the human chromosome 8p11-12 near
the Werner syndrome gene locus is described. The single-copy RBP-MS gene is
alternatively spliced, resulting in a family of at least 12 transcripts (average
length of 1.5 kb). Nine different types of cDNAs that encode an RNa-binding
motif at the N terminus and helix-rich sequences at the C terminus have been
identified thus far. Among the 16 exons identified, four 5'-proximal exons
contained sequences homologous to the RNA-binding domain of Drosophila couch
potato gene. Northern blot analysis showed that the RBP-MS gene was expressed
strongly in the heart, prostate, intestine, and ovary, and poorly in the
skeletal muscle, spleen, thymus, brain, and peripheral leukocytes. The possible
role of this gene in RNA metabolism is discussed.
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