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Title
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Crystal structure of cyclin-dependent kinase 2.
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Authors
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H.L.De Bondt,
J.Rosenblatt,
J.Jancarik,
H.D.Jones,
D.O.Morgan,
S.H.Kim.
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Ref.
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Nature, 1993,
363,
595-602.
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PubMed id
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Abstract
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Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of
protein kinases that regulate the eukaryotic cell cycle. The crystal structures
of the human CDK2 apoenzyme and its Mg2+ ATP complex have been determined to 2.4
A resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent
protein kinase, but contains a unique helix-loop segment that interferes with
ATP and protein substrate binding and probably plays a key part in the
regulation of all cyclin-dependent kinases.
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