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Title
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Rational design of potent sialidase-based inhibitors of influenza virus replication.
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Authors
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M.von Itzstein,
W.Y.Wu,
G.B.Kok,
M.S.Pegg,
J.C.Dyason,
B.Jin,
T.Van Phan,
M.L.Smythe,
H.F.White,
S.W.Oliver.
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Ref.
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Nature, 1993,
363,
418-423.
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PubMed id
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Abstract
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Two potent inhibitors based on the crystal structure of influenza virus
sialidase have been designed. These compounds are effective inhibitors not only
of the enzyme, but also of the virus in cell culture and in animal models. The
results provide an example of the power of rational, computer-assisted drug
design, as well as indicating significant progress in the development of a new
therapeutic or prophylactic treatment for influenza infection.
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