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Title
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Structural, functional and evolutionary implications of the three-dimensional crystal structure of murine interferon-beta.
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Authors
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Y.Mitsui,
T.Senda,
T.Shimazu,
S.Matsuda,
J.Utsumi.
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Ref.
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Pharmacol Ther, 1993,
58,
93.
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PubMed id
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Abstract
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The crystal structure of recombinant murine interferon-beta as elucidated by
Senda et al. (Proc. Jap. Acad. 66B: 77-80 (1990); EMBO J. 11: 3193-3201 (1992))
appears to represent the basic structural framework of all Type I interferons
including interferons-beta and all subtypes of interferons-alpha of various
mammalian origin. Now the huge accumulated data on the structure-activity
relationship of Type I interferons using various chemical and genetic techniques
can be systematically evaluated in terms of the three-dimensional structure.
Structural comparison with other cytokines, for which three-dimensional
structures have been established, including interferon-gamma and considerations
on the evolution of cytokines and cytokine receptors are also given.
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