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Title
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The immunodominant 38-kDa lipoprotein antigen of Mycobacterium tuberculosis is a phosphate-binding protein.
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Authors
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Z.Chang,
A.Choudhary,
R.Lathigra,
F.A.Quiocho.
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Ref.
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J Biol Chem, 1994,
269,
1956-1958.
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PubMed id
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Abstract
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Several antigens of Mycobacterium tuberculosis have been identified by
monoclonal antibodies and are being exploited in the development of improved
vaccines and diagnostic reagents, but none has been linked to a specific
function. Herein we report that the 38-kDa extracellular lipoprotein antigen,
the most potent immunogen of the mycobacteria, is a phosphate-binding protein
with features very similar to those of the well characterized periplasmic
phosphate-binding protein of Escherichia coli which serves as an initial
receptor for active transport. This is also the first report definitively
linking a function of a binding protein anchored to a membrane and found in
other than Gram-negative bacteria.
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