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Title
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Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution.
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Authors
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J.N.Varghese,
W.G.Laver,
P.M.Colman.
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Ref.
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Nature, 1983,
303,
35-40.
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PubMed id
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Abstract
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The influenza virus neuraminidase glycoprotein is a tetramer with a box-shaped
head, 100 X 100 X 60 A, attached to a slender stalk. The three-dimensional
structure of neuraminidase heads shows that each monomer is composed of six
topologically identical beta-sheets arranged in a propeller formation. The
tetrameric enzyme has circular 4-fold symmetry stabilized in part by metal ions
bound on the symmetry axis. Sugar residues are attached to four of the five
potential glycosylation sequences, and in one case contribute to the interaction
between subunits in the tetramer.
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