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Title
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The nucleotide sequence of poliovirus type 3 leon 12 a1b: comparison with poliovirus type 1.
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Authors
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G.Stanway,
A.J.Cann,
R.Hauptmann,
P.Hughes,
L.D.Clarke,
R.C.Mountford,
P.D.Minor,
G.C.Schild,
J.W.Almond.
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Ref.
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Nucleic Acids Res, 1983,
11,
5629-5643.
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PubMed id
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Abstract
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The complete nucleotide sequence of the genome of the Sabin vaccine strain of
poliovirus type 3 (P3/Leon 12 a1 b) has been determined from cDNA cloned in E.
coli. The genome comprises a 5' non-coding region of 742 nucleotides, a large
open reading frame of 6618 nucleotides (89% of the sequence) and a 3' non-coding
region of 72 nucleotides. There is 77.4% base-sequence homology and 89.6%
predicted amino-acid homology between types 1 and 3. Conservation of all
glutamine-glycine and tyrosine-glycine cleavage sites suggests a mechanism of
polyprotein processing similar to that established for poliovirus type 1.
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