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Title
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Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein.
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Authors
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D.Pennica,
W.J.Kohr,
W.J.Kuang,
D.Glaister,
B.B.Aggarwal,
E.Y.Chen,
D.V.Goeddel.
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Ref.
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Science, 1987,
236,
83-88.
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PubMed id
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Abstract
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The primary structure of human uromodulin, a 616-amino acid, 85-kilodalton
glycoprotein with in vitro immunosuppressive properties, was determined through
isolation and characterization of complementary DNA and genomic clones. The
amino acid sequence encoded by one of the exons of the uromodulin gene has
homology to the low-density-lipoprotein receptor and the epidermal growth factor
precursor. Northern hybridization analyses demonstrate that uromodulin is
synthesized by the kidney. Evidence is provided that uromodulin is identical to
the previously characterized Tamm-Horsfall glycoprotein, the most abundant
protein in normal human urine.
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