 |
|
Title
|
|
Structure of a human common cold virus and functional relationship to other picornaviruses.
|
|
|
Authors
|
|
M.G.Rossmann,
E.Arnold,
J.W.Erickson,
E.A.Frankenberger,
J.P.Griffith,
H.J.Hecht,
J.E.Johnson,
G.Kamer,
M.Luo,
A.G.Mosser.
|
|
|
Ref.
|
|
Nature, 1985,
317,
145-153.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
We report the first atomic resolution structure of an animal virus, human
rhinovirus 14. It is strikingly similar to known icosahedral plant RNA viruses.
Four neutralizing immunogenic regions have been identified. These, and
corresponding antigenic sequences of polio and foot-and-mouth disease viruses,
reside on external protrusions. A large cleft on each icosahedral face is
probably the host cell receptor binding site.
|
|
|
|