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Title
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The cellobiose permease of Escherichia coli consists of three proteins and is homologous to the lactose permease of Staphylococcus aureus.
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Authors
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J.Reizer,
A.Reizer,
M.H.Saier.
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Ref.
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Res Microbiol, 1990,
141,
1061-1067.
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PubMed id
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Abstract
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The cellobiose (cel) operon of Escherichia coli was recently sequenced and shown
to consist of five genes, celABCDF (Parker and Hall, 1990). We have shown that
the CelA, CelB and CelC proteins possess amino acid sequences which are
homologous to different domains of the lactose permease of Staphylococcus
aureus. CelB corresponds to the integral membrane portion of the permease
(IIcel) while CelC (IIIcel) and CelA (IVcel) correspond to the two cytoplasmic
domains which appear to comprise the first and second phosphorylation sites in
the permease, respectively. The cellobiose permease is the only one of several
homologous sequenced permeases of the phosphoenolpyruvate:sugar
phosphotransferase system which has its three known functional domains residing
on distinct polypeptide chains.
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