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Title
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Conserved fungal LysM effector Ecp6 prevents chitin-triggered immunity in plants.
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Authors
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R.de Jonge,
H.P.van Esse,
A.Kombrink,
T.Shinya,
Y.Desaki,
R.Bours,
S.van der Krol,
N.Shibuya,
M.H.Joosten,
B.P.Thomma.
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Ref.
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Science, 2010,
329,
953-955.
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PubMed id
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Abstract
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Multicellular organisms activate immunity upon recognition of
pathogen-associated molecular patterns (PAMPs). Chitin is the major component of
fungal cell walls, and chitin oligosaccharides act as PAMPs in plant and
mammalian cells. Microbial pathogens deliver effector proteins to suppress
PAMP-triggered host immunity and to establish infection. Here, we show that the
LysM domain-containing effector protein Ecp6 of the fungal plant pathogen
Cladosporium fulvum mediates virulence through perturbation of chitin-triggered
host immunity. During infection, Ecp6 sequesters chitin oligosaccharides that
are released from the cell walls of invading hyphae to prevent elicitation of
host immunity. This may represent a common strategy of host immune suppression
by fungal pathogens, because LysM effectors are widely conserved in the fungal
kingdom.
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