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Title
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Complexity and simplicity in the biosynthesis of enediyne natural products.
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Author
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Z.X.Liang.
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Ref.
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Nat Prod Rep, 2010,
27,
499-528.
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PubMed id
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Abstract
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The review highlights the recent progress on the elucidation of the biosynthetic
mechanism of enediyne natural products. A large body of knowledge has been
gathered from the genetic, biochemical and structural studies since the
sequencing of the first two enediyne gene clusters in 2002. Primary attention is
devoted to the novel pathways and enzymes in the biosynthesis of the enediyne
warhead as well as the peripheral moieties.
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