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Title
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Protein-DNA and protein-hormone interactions in prealbumin: a model of the thyroid hormone nuclear receptor?
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Authors
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C.C.Blake,
S.J.Oatley.
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Ref.
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Nature, 1977,
268,
115-120.
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PubMed id
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Abstract
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High resolution X-ray analysis of the hormone-binding protein prealbumin has
shown that it has a structural complementarity to double-helical DNA. The
proposed binding site is composed of two symmetry-related beta-sheets containing
a pair of helically disposed arms, which can interact with the bases in the wide
groove of DNA. A palindromic target sequence is indicated by the symmetry of the
protein. The two identical thyroid hormone binding sites on prealbumin are
located in a channel that runs completely through the molecule. These two
structural features suggest prealbumin as a model for the thyroid hormone
nuclear receptor, providing a number of detailed predictions of its properties.
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