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Title
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The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation.
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Authors
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D.R.Madden,
J.C.Gorga,
J.L.Strominger,
D.C.Wiley.
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Ref.
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Nature, 1991,
353,
321-325.
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PubMed id
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Abstract
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X-ray crystallography reveals electron density in the antigen-binding site of
HLA-B27 that is an interpretable image of nonameric peptides in a largely
extended conformation. Clear density exists for the main chain and several side
chains and is consistent with the sequence of 11 nonameric self-peptides eluted
from HLA-B27. Pockets in the antigen-binding cleft bind four side chains and the
amino and carboxyl termini of the peptide.
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