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Title
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A new folding paradigm for repeat proteins.
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Authors
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T.Kajander,
A.L.Cortajarena,
E.R.Main,
S.G.Mochrie,
L.Regan.
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Ref.
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J Am Chem Soc, 2005,
127,
10188-10190.
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PubMed id
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Abstract
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The folding/unfolding transitions of a series of designed consensus
tetratricopeptide repeat proteins are quantitatively described by the classical
one-dimensional Ising model, which thus represents a new folding paradigm for
repeat proteins. Moreover, for the first time for any protein, a theoretical
model predicts the folding/unfolding transition midpoint and the width of the
transition.
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