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Title
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Structure of the mitochondrial beta-ketoacyl-[acyl carrier protein] synthase from Arabidopsis and its role in fatty acid synthesis.
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Authors
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J.G.Olsen,
A.V.Rasmussen,
P.von Wettstein-Knowles,
A.Henriksen.
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Ref.
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FEBS Lett, 2004,
577,
170-174.
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PubMed id
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Abstract
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Mitochondrial fatty acid synthesis is catalyzed by a dissociated fatty acid
synthase similar to those of plant plastids and bacteria. The crystal structure
of a mitochondrial beta-ketoacyl-[acyl carrier protein] synthase (mtKAS), namely
that from Arabidopsis thaliana, has been determined for the first time. This
enzyme accomplishes the vital condensation steps in constructing fatty acid
carbon skeletons. The product profile of mtKAS is unusual in that C8 and
C(14-16) fatty acyl chains predominate. An enzyme architecture that likely is
the basis for the observed bimodal profile of mtKAS products can be derived from
the shape of the acyl binding pocket.
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