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Title
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Crystal structure of staphylococcal enterotoxin B, a superantigen.
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Authors
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S.Swaminathan,
W.Furey,
J.Pletcher,
M.Sax.
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Ref.
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Nature, 1992,
359,
801-806.
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PubMed id
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Abstract
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The three-dimensional structure of staphylococcal enterotoxin B, which is both a
toxin and a super-antigen, has been determined to a resolution of 2.5 A. The
unusual main-chain fold containing two domains may represent a general motif
adopted by all staphylococcal enterotoxins. The T-cell receptor binding site
encompasses a shallow cavity formed by both domains. The MHCII molecule binds to
an adjacent site. Another cavity with possible biological activity was also
identified.
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