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Title
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A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor.
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Authors
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P.Bork,
C.Sander.
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Ref.
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Febs Lett, 1992,
300,
237-240.
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PubMed id
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Abstract
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A new family of mosaic proteins is defined by sequence analysis. The family is
characterized by a 260 residue domain common to proteins of apparently diverse
function and tissue specificity: sperm receptors Zp2 and Zp3, betaglycan (also
called TGF-beta type III receptor), uromodulin, as well as the major zymogen
granule membrane protein (GP-2). The location of the common domain is similar
with respect to putative transmembrane regions. The results lead to the
hypothesis that this type of domain has a common tertiary structure and that
there is a functional similarity in the recognition mechanism of the sperm
receptor system and the TGF-beta receptor complex.
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