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Title
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Conformational features of the four successive non-Watson-Crick base pairs in RNA duplex.
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Authors
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S.Fujii,
Y.Tanaka,
S.Uesugi,
T.Tanaka,
T.Sakata,
H.Hiroaki.
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Ref.
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Nucleic Acids Symp Ser, 1992,
27,
63-64.
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PubMed id
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Abstract
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A tridecaribonucleotide, r(UGAGCUUCGGCUC) doesn't form hairpin or interior loop
and forms a double helix of 12 base pairs including the four successive
nonstandard base pairs, U.G-U.C-C.U-G.U, in the crystal. Non-Watson-Crick base
pairs, G.U and U.C are nicely incorporated in RNA duplex maintaining the regular
A-form backbone. There exist the good overlapping between base pairings, U.G and
U.C, so as to stabilize the nonstandard base pair track. Hydrogen bond networks
involving water molecules in the major and minor grooves to stabilize this
mismatch base pairing array, are observed and its conformational features are
described.
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