 |
|
Title
|
|
Structure and assembly of the spliceosomal small nuclear ribonucleoprotein particles.
|
|
|
Authors
|
|
C.Kambach,
S.Walke,
K.Nagai.
|
|
|
Ref.
|
|
Curr Opin Struct Biol, 1999,
9,
222-230.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
The spliceosome is a macromolecular assembly that carries out the excision of
introns from nuclear pre-mRNAs. It consists of four large RNA-protein complexes,
called the U1, U2, U4/U6 and U5 small nuclear ribonucleoproteins (snRNPs), and
many protein factors. Crystal structures of seven protein components and
fragments of the U1 and U2 small nuclear RNAs have been determined in the form
of RNA-protein and protein-protein complexes. Together with electron microscopy
studies of the snRNPs, these structures have begun to provide important insights
into the architecture of the snRNPs and the mechanisms of RNA-protein and
protein-protein recognition.
|
|
|
|