|
|
||
|
|
|
|
|
UniProt functional annotation for Q86UW1 | ||
|
|
|
|
|
|
||
| UniProt code: Q86UW1. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. {ECO:0000269|PubMed:16317684}. |
|
||
| Subunit: | |
Interacts with SLC51B. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B (By similarity). Mainly restricted to the lateral and basal membranes of ileal enterocytes. {ECO:0000250}. |
| Tissue specificity: | |
Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat. {ECO:0000269|PubMed:12719432, ECO:0000269|PubMed:16317684}. |
| Induction: | |
Positively regulated via NR1H4/FXR in adrenal gland, kidney and intestine. {ECO:0000269|PubMed:16251721, ECO:0000269|PubMed:16269519}. |
| Similarity: | |
Belongs to the OST-alpha family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.