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UniProt functional annotation for Q79PF4 | ||
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| UniProt code: Q79PF4. |
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| Organism: | |
Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans R2). |
| Taxonomy: | |
Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus. |
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| Function: | |
Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. {ECO:0000269|PubMed:14709675, ECO:0000269|PubMed:9727980}. |
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| Catalytic activity: | |
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; |
| Catalytic activity: | |
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:15304218}; |
| Activity regulation: | |
The interaction with KaiA enhances its phosphorylation status, while the interaction with KaiB decreases it. A KaiA dimer is sufficient to enhance KaiC phosphorylation. {ECO:0000269|PubMed:12391300, ECO:0000269|PubMed:12727878, ECO:0000269|PubMed:12727879}. |
| Subunit: | |
Homohexamer; hexamerization is dependent on ATP-binding. Core component of the KaiABC complex, at least composed of a KaiC homohexamer, a KaiB dimer and two KaiA dimers. Interacts directly with SasA. {ECO:0000269|PubMed:10064581, ECO:0000269|PubMed:10786837, ECO:0000269|PubMed:11356188, ECO:0000269|PubMed:12727878, ECO:0000269|PubMed:12727879}. |
| Developmental stage: | |
Accumulates in a circadian fashion, peaking at circadian time (CT) 15-18. {ECO:0000269|PubMed:15229218}. |
| Induction: | |
Down-regulated by itself. {ECO:0000269|PubMed:14709675}. |
| Domain: | |
The KaiC domains mediate the interaction with KaiA. |
| Ptm: | |
Phosphorylated on serine/threonine residues by autocatalysis. Both phosphorylated and unphosphorylated forms exist. Can probably autophosphorylate and autodephosphorylate. Phosphorylated form correlates with clock speed. {ECO:0000269|PubMed:12391300, ECO:0000269|PubMed:12727878, ECO:0000269|PubMed:12727879}. |
| Miscellaneous: | |
'Kai' means 'cycle' in Japanese. |
| Similarity: | |
Belongs to the KaiC family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.