PDBsum entry 9lyb

Structural protein

PDB id: 9lyb

Contents

Protein chains

240 a.a.

339 a.a.

58 a.a.

128 a.a.

272 a.a.

PDB id:

9lyb

Name:

Structural protein

Title:

Cryo-em structure of gpr3-g protein-monomer complex

Structure:

Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: gpr3, acca.

Authors:

T.Hua,Z.J.Liu,X.T.Li,H.Chang

Key ref:

H.Chang et al. (2025). Structural basis of oligomerization-Modulated activat autoinhibition of orphan receptor gpr3.. Cell rep, 44, . PubMed id: 40158220

Date:

19-Feb-25 Release date: 09-Apr-25

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 240 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 58 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

P46089  (GPR3_HUMAN) -  G-protein coupled receptor 3 from Homo sapiens

Seq: 330 a.a.

Struc: 272 a.a.

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????