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UniProt functional annotation for Q9NYV7 | ||
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| UniProt code: Q9NYV7. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. {ECO:0000269|PubMed:12379855, ECO:0000269|PubMed:15759003}. |
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| Subunit: | |
Interacts with RTP3 and RTP4. {ECO:0000269|PubMed:16720576}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:16720576}; Multi-pass membrane protein {ECO:0000255}. |
| Tissue specificity: | |
Expressed in a subset of gustducin-positive taste receptor cells of the tongue. Expressed in circumvallate papillae and testis (PubMed:16720576). {ECO:0000269|PubMed:16720576}. |
| Polymorphism: | |
Genetic variation in TAS2R16 influences sensitivity to beta-glucopyranoside tasting (BGLPT) [MIM:617956]. Variant Asn-172 results in greater receptor activation in response to bitter beta- glucopyranoside compounds including salicin, arbutin and amygdalin compared to Lys-172 (PubMed:16051168). Variant Lys-172 may influence risk of alcohol dependence (PubMed:16385453). {ECO:0000269|PubMed:16051168, ECO:0000269|PubMed:16385453}. |
| Miscellaneous: | |
Several bitter taste receptors are expressed in a single taste receptor cell. |
| Miscellaneous: | |
Confers bitter perception of salicin to non-taster mice. |
| Similarity: | |
Belongs to the G-protein coupled receptor T2R family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.