PDBsum entry 9kfi

Structural proten/immune system

PDB id: 9kfi

Contents

Protein chains

307 a.a.

55 a.a.

219 a.a.

230 a.a.

338 a.a.

22 a.a.

24 a.a.

PDB id:

9kfi

Name:

Structural proten/immune system

Title:

Cryo-em structure of the human relaxin family peptide receptor 3 in complex with relaxin-3 and g protein

Structure:

Soluble cytochrome b562,relaxin-3 receptor 1,lgbit. Chain: c. Synonym: cytochrome b-562,rln3 receptor 1,g protein-coupled receptor salpr,g-protein coupled receptor gpcr135,relaxin family peptide receptor 3,somatostatin- and angiotensin-like peptide receptor. Engineered: yes. Mutation: yes. Other_details: bril. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Escherichia coli, homo sapiens, synthetic construct. Human. Organism_taxid: 562, 9606, 32630. Gene: cybc, rxfp3, gpcr135, rln3r1, salpr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Organism_taxid: 9606.

Authors:

Y.Chen,Q.T.Zhou,S.Y.Yan,J.H.Yan,D.H.Yang,J.Chen,M.W.Wang

Key ref:

Y.Chen et al. (2025). Molecular mechanism underlying non-Discriminatory recognition of relaxin-3 by rxfp3 and rxfp4.. Commun biol, 8, 794. PubMed id: 40410443 DOI: 10.1038/S42003-025-08220-7

Date:

06-Nov-24 Release date: 13-Aug-25

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 307 a.a.*

Protein chain

Q9NSD7  (RL3R1_HUMAN) -  Relaxin-3 receptor 1 from Homo sapiens

Seq: 469 a.a.

Struc: 307 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

P04899  (GNAI2_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-2 from Homo sapiens

Seq: 355 a.a.

Struc: 219 a.a.*

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

Q8WXF3  (REL3_HUMAN) -  Relaxin-3 from Homo sapiens

Seq: 142 a.a.

Struc: 22 a.a.

Protein chain

Q8WXF3  (REL3_HUMAN) -  Relaxin-3 from Homo sapiens

Seq: 142 a.a.

Struc: 24 a.a.

* PDB and UniProt seqs differ at 166 residue positions (black crosses)