PDBsum entry 9jr3

Signaling protein/immune system

PDB id: 9jr3

Contents

Protein chains

355 a.a.

35 a.a.

220 a.a.

337 a.a.

51 a.a.

231 a.a.

Ligands

NAG-NAG

Waters ×1

PDB id:

9jr3

Name:

Signaling protein/immune system

Title:

Cryo-em structure of pth-pth1r-gq (tilted state)

Structure:

Parathyroid hormone/parathyroid hormone-related peptide receptor. Chain: r. Synonym: pth/pthrp type i receptor,pth/pthr receptor,parathyroid hormone 1 receptor,pth1 receptor. Engineered: yes. Parathyroid hormone. Chain: p. Synonym: pth,parathormone,parathyrin.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pth1r, pthr, pthr1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Synthetic: yes. Expressed in: spodoptera frugiperda.

Authors:

F.K.Sano,H.Hirano,Y.Itoh,O.Nureki

Key ref:

F.K.Sano et al. Insights into g-Protein coupling preference from cryo structures of gq-Bound pth1r. To be published, . PubMed id: 40571720

Date:

29-Sep-24 Release date: 16-Oct-24

Protein chain

Q03431  (PTH1R_HUMAN) -  Parathyroid hormone/parathyroid hormone-related peptide receptor from Homo sapiens

Seq: 593 a.a.

Struc: 355 a.a.

Protein chain

P01270  (PTHY_HUMAN) -  Parathyroid hormone from Homo sapiens

Seq: 115 a.a.

Struc: 35 a.a.*

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 220 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 337 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 51 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

* PDB and UniProt seqs differ at 59 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????