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UniProt functional annotation for Q6QNK2 | ||
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| UniProt code: Q6QNK2. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Orphan receptor. Signals via G(s)-alpha family of G-proteins (PubMed:22025619, PubMed:22575658). Has protumorigenic function especially in glioblastoma (PubMed:27775701). {ECO:0000269|PubMed:22025619, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:27775701}. |
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| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:22025619, ECO:0000269|PubMed:25533341}; Multi-pass membrane protein {ECO:0000255}. |
| Tissue specificity: | |
Up-regulated in CD133(+) cell population of glioblastoma. {ECO:0000269|PubMed:27775701}. |
| Induction: | |
Up-regulated by hypoxia in hypoxia-inducible factor 1-alpha (HIF1A)-dependent manner. {ECO:0000269|PubMed:27775701}. |
| Domain: | |
A short peptide sequence (termed the Stachel sequence) in the C-terminal part of the extracellular domain (ECD) functions as a tethered agonist. Upon structural changes within the ECD, e.g. due to extracellular ligand binding or mechanical movements, this intramolecular agonist is exposed to the 7 transmembrane region, triggering G-protein activation. {ECO:0000269|PubMed:25533341}. |
| Domain: | |
The N-terminal domain and autocatalytic activity of ADGRD1 at the GPCR proteolysis site (GPS) are not required for G-protein coupling activity. {ECO:0000269|PubMed:22025619}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.