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UniProt functional annotation for Q16581 | ||
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| UniProt code: Q16581. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. |
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| Subunit: | |
Interacts with VGF-derived peptide TLQP-21 (By similarity). {ECO:0000250|UniProtKB:O09047}. |
| Subcellular location: | |
Cell membrane; Multi-pass membrane protein. |
| Tissue specificity: | |
Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues. |
| Ptm: | |
Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin. {ECO:0000269|PubMed:12871936}. |
| Ptm: | |
O-glycosylated. {ECO:0000269|PubMed:23234360}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
Annotations taken from UniProtKB at the EBI.