|
|
||
|
|
|
|
|
UniProt functional annotation for P13945 | ||
|
|
|
|
|
|
||
| UniProt code: P13945. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis. |
|
||
| Subunit: | |
Interacts with ARRDC3. {ECO:0000269|PubMed:21982743}. |
| Subcellular location: | |
Cell membrane; Multi-pass membrane protein. |
| Tissue specificity: | |
Expressed mainly in adipose tissues. |
| Polymorphism: | |
The variant Arg-64 seems to be associated with weight gain (obesity) and is also associated with susceptibility to non- insulin-dependent diabetes mellitus (NIDDM). {ECO:0000269|PubMed:8721782, ECO:0000305|PubMed:7609752}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
Annotations taken from UniProtKB at the EBI.