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UniProt functional annotation for Q02201 | ||
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| UniProt code: Q02201. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1 phosphatase in the endoplasmic reticulum (PubMed:23934110, PubMed:26206936). Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206936). {ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206936}. |
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| Subcellular location: | |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:20008566, ECO:0000269|PubMed:23934110}. Note=Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites. {ECO:0000269|PubMed:20008566, ECO:0000269|PubMed:23934110}. |
| Miscellaneous: | |
Present with 2550 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the OSBP family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.