|
|
||
|
|
|
|
|
UniProt functional annotation for Q8TD46 | ||
|
|
|
|
|
|
||
| UniProt code: Q8TD46. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. {ECO:0000269|PubMed:12960329}. |
|
||
| Subunit: | |
CD200 and CD200R1 interact via their respective N-terminal Ig- like domains (By similarity). Interacts with Human herpesvirus 8 vOX2 protein. {ECO:0000250}. |
| Subunit: | |
(Microbial infection) Interacts with human herpesvirus 8/HHV-8 protein vOX2/K14. {ECO:0000269|Ref.2}. |
| Subcellular location: | |
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. |
| Subcellular location: | |
[Isoform 4]: Cell membrane; Single-pass type I membrane protein. |
| Subcellular location: | |
[Isoform 2]: Secreted. |
| Subcellular location: | |
[Isoform 3]: Secreted. |
| Tissue specificity: | |
Expressed in granulocytes, monocytes, most T-cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells. {ECO:0000269|PubMed:12960329}. |
| Ptm: | |
The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform. |
| Similarity: | |
Belongs to the CD200R family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.