UniProt functional annotation for Q9IK91



	UniProt functional annotation for Q9IK91

UniProt code: Q9IK91.

Organism: Nipah virus.

Taxonomy: Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae; Henipavirus.

Function: Essential component of the RNA polymerase transcription and replication complex. Binds the viral ribonucleocapsid and positions the L polymerase on the template (By similarity). May play a role to prevent the establishment of cellular antiviral state by binding to host STAT1 in the cytoplasm. This activity is not as strong as that of V and W. {ECO:0000250}.

Subunit: Interacts with host STAT1. {ECO:0000269|PubMed:15140960}.

Subcellular location: Virion. Host cytoplasm.

Rna editing: Modified_positions=406; Note=Partially edited. RNA editing at this position consists of an insertion of one or two guanine nucleotides. The sequence displayed here is the P protein, derived from the unedited RNA. The edited RNA gives rise to the V protein (+1G) (AC Q997F2), and the W protein (+2G) (AC P0C1C7).;

Miscellaneous: The P/V/C gene has two overlapping open reading frames. One encodes the P/V/W proteins and the other the C protein.

Annotations taken from UniProtKB at the EBI.


Organism:		Nipah virus.
Taxonomy:		Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae; Henipavirus.



Function:		Essential component of the RNA polymerase transcription and replication complex. Binds the viral ribonucleocapsid and positions the L polymerase on the template (By similarity). May play a role to prevent the establishment of cellular antiviral state by binding to host STAT1 in the cytoplasm. This activity is not as strong as that of V and W. {ECO:0000250}.


Subunit:		Interacts with host STAT1. {ECO:0000269\|PubMed:15140960}.
Subcellular location:		Virion. Host cytoplasm.
Rna editing:		Modified_positions=406; Note=Partially edited. RNA editing at this position consists of an insertion of one or two guanine nucleotides. The sequence displayed here is the P protein, derived from the unedited RNA. The edited RNA gives rise to the V protein (+1G) (AC Q997F2), and the W protein (+2G) (AC P0C1C7).;
Miscellaneous:		The P/V/C gene has two overlapping open reading frames. One encodes the P/V/W proteins and the other the C protein.